Brian is born in a stable on Christmas, right next to You Know Who. The wise men appear and begin to distribute gifts. The star moves further, so they take it all back and move on. This is how Brian's life goes. The Jews are looking for a release from the Romans, Spiritual and political decay, keep looking for signs and a group decides Brian is the Messiah. He cannot convince them he is not. He joins the Peoples' Front of Judea, one of several dozen separatist groups who actually do nothing, but really hate the Romans. While not about Jesus, it is about those who hadn't time, or interest to listen to his message. Many Political and Social comments.
Returning from a year up the Amazon studying snakes, the rich but unsophisticated Charles Pike meets con-artist Jean Harrington on a ship. They fall in love, but a misunderstanding causes them to split on bad terms. To get back at him, Jean disguises herself as an English lady, and comes back to tease and torment him.
Wayne Szalinski is at it again. But instead of shrinking things, he tries to make a machine that can make things grow. As in the first one, his machine isn't quite accurate. But when he brings Nick & his toddler son Adam to see his invention, the machine unexpectedly starts working. And when Adam comes right up to the machine, he gets zapped along with his stuffed bunny. Now, whenever Adam comes near anything electrical, the electricity causes him to grow. Adam soon starts to grow to the height of 150 feet. And he is now walking through Las Vegas which he thinks is one big play land.
George is now a father to Junior. He is also Ursula's husband and the king of the jungle. Because of this, George finds it hard to balance his time between his different roles. Even worse, Ursula's mother Beatrice comes back to try and bring Junior and Ursula back to civilization along with Lyle van de Groot, who also plans to steal the deed to Ape Mountain. After hearing Ape is in trouble, George takes Ursula and Junior to Vegas. Lyle steals the deed to Ape Mountain and sends bulldozers there. He also hires a hypnotist that makes Ursula forget George. George is suddenly torn between saving the jungle, or getting back the family he loves.
When his father - who owned a circus - dies, Oscar inherits 5 million dollars - and 3 orang outangs. However there's a condition connected to the money: if he gives away the apes or just one gets sick or dies during the next 3 years, the zoologic society will get all the money. So he not only has to deal with 3 apes and an annoyed girlfriend, but also with a greedy zoologic society's president.